Antimicrobial and hypoglycemic effects of Elaeocarpus Ganitrus Seed

Authors

  • subhashish tripathy Dept. Pharmaceutical Science OPJS University1-2, Churu, Rajasthan- India
  • Anil Mida OPJS University,Churu, Rajasthan- India

Keywords:

Antibacterial, Antifungal, Hypoglycemic, Elaeocarpus Ganitrus.

Abstract

The Evaluation of the antibacterial, antifungal and hypoglycemic effects of methanol and water (ratio70:30) extract of Elaeocarpus Ganitrus seeds were investigated by using the cup bore agar diffusion method and hypoglycemic effect was evaluated in alloxan induced diabetic rats. The extract of E.Ganitrus seed significantly inhibited Bacillus subtilis, Staphylococcus aureus (Gram positive), Klebsiella pneumonia, Escherichia  coli, Salmonella typhi,  Proteus  vulgaris and Pseudomonas aeruginosa (Gram-negative) to varying degrees, but it had little  inhibitory effect on fungal species (Aspergillus  niger,  Aspergillus  fumigatus, Mucor  pusillus  (fungi), and Candida albicans  (yeast).For anti bacterial study Gentamycin, the standard antibacterial drug used for inhibiting these bacteria. The effect on B.  subtilis and E. coli were similar to that of gentamycin. Ketoconazole, the regular ant fungicide used was effective against all the fungi and yeast species. The extract of E.Ganitrus seed also significantly (P<0.05) reduced blood glucose level in alloxan induced diabetic rats twelve hours after administration. The effect of the extract at 1000mg/kg was comparable to that of the standard drug (chlorpropamide) used.  Results support some of the traditional uses of E.Ganitrus seed as an anti-infective herb and for the management of diabetic sores

Author Biographies

  • subhashish tripathy, Dept. Pharmaceutical Science OPJS University1-2, Churu, Rajasthan- India
    Reserach scholar, O.P.J.S University
  • Anil Mida, OPJS University,Churu, Rajasthan- India
    Department Pharmacetical Science OPJS University, Rajasthan

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Additional Files

Published

2016-12-04